NR Tartrate

What is NR Tartrate?

The UltiNADⓇ NR Tartrate is nicotinamide riboside L-tartrate, which is JARI NUTRA’s form of nicotinamide riboside (NR). As long as Nicotinamide Mononucleotide (NMN), NR is a member of the vitamin B3 family, it can convert to nicotinamide adenine dinucleotide (NAD+) in cell and increase the cellular concentration of NAD+, which is a vital resource found in all living cells.

Structure

Chemical Name: Nicotinamide Riboside L-tartrate

Molecular Weight: 404.33

Molecular Formula: C15H20N2O11

CAS No.: 2415657-86-0

Why is UltiNAD® NR Tartrate?

As known, NR can safely and effectively increase NAD+ in humans. UltiNADⓇ NR Tartrate is L-tartrate form of NR, comparison with other NR forms, especially NR chloride, UltiNADⓇ NR Tartrate, UltiNADⓇ NR Tartrate exhibits almost the same bioavailability, but the stability of UltiNADⓇ NR Tartrate is much better than others. In other words, with the same effectiveness, UltiNADⓇ NR Tartrate is more convenient for storage and transportation.

Tasty

Not like other NR form, such as NR chloride which was a bitter tasty, UltiNADⓇ NR Tartrate has good tasty which is delicious with slight sweetness and sour, so UltiNADⓇ NR Tartrate is suitable for making gummies, granules and other forms. It greatly increases the range of applications of UltiNADⓇ NR Tartrate as a food supplement.

Stability

Time (h)

NR-Cl

UltiNADⓇ NR Tartrate

0 day

99.10%

99.90%

5 day

95.50%

99.80%

10 day

91.80%

99.90%

20 day

86.60%

99.80%

30 day

74.20%

99.70%

60 day

48.70%

99.60%

120 day

25.50%

99.60%

180 day

12.30%

99.50%

Stability studies under controlled conditions show UltiNADⓇ NR Tartrate has high stability under ambient conditions (25° C and 60% relative humidity) and accelerated conditions (40°C and 75% relative humidity) , but nicotinamide riboside chloride (NR-Cl) decompose fast under the same conditions.

Bioavailability

Time (h)

NR-Cl

MR-Malate

UltiNADⓇ NR Tartrate

6

67167

72333

72500

24

62667

51200

60667

The Blood concentrations of NAD+ after a single intragastric administration of NR-Cl, NR-Malate and UltiNADⓇ NR Tartrate in mices are shown the peak concentration were no significant difference between the different dosage forms base on Cmax and AUC0-t. That means UltiNADⓇ NR Tartrate is the same bioavailability as other form of NR.

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